Intoxication

Temporal Bone Image Library

  • Title: Streptomycin ototoxicity, L-71
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 799
  • Comments: This was a 53-year old male who received 1 gram of Streptomycin by systemic administration every day for 10 days at the age of 47. Following this medication, he became very ataxic and suffered from oscillopsia. There was no response to ice water caloric testing
  • Gender: Male
  • Age(yrs.): 53
  • otologic_dx:

    1. Streptomycin ototoxicity, manifested by oscillopsia, ataxia and loss of caloric responses

    2. Loss of hair cells, cristae, bilateral

    3. Preservation of hair cells of maculae of utricle and saccule

    4. Sclerosis of mastoid, right, mild

  • Title: Streptomycin ototoxicity, L-71
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 799
  • Comments: This was a 53-year old male who received 1 gram of Streptomycin by systemic administration every day for 10 days at the age of 47. Following this medication, he became very ataxic and suffered from oscillopsia. There was no response to ice water caloric testing
  • Gender: Male
  • Age(yrs.): 53
  • otologic_dx:

    1. Streptomycin ototoxicity, manifested by oscillopsia, ataxia and loss of caloric responses

    2. Loss of hair cells, cristae, bilateral

    3. Preservation of hair cells of maculae of utricle and saccule

    4. Sclerosis of mastoid, right, mild

  • Title: Streptomycin ototoxicity, L-71
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 799
  • Comments: This was a 53-year old male who received 1 gram of Streptomycin by systemic administration every day for 10 days at the age of 47. Following this medication, he became very ataxic and suffered from oscillopsia. There was no response to ice water caloric testing
  • Gender: Male
  • Age(yrs.): 53
  • otologic_dx:

    1. Streptomycin ototoxicity, manifested by oscillopsia, ataxia and loss of caloric responses

    2. Loss of hair cells, cristae, bilateral

    3. Preservation of hair cells of maculae of utricle and saccule

    4. Sclerosis of mastoid, right, mild

  • Title: Normal lateral canal crista, R-61
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 672
  • Comments: This case is that of a 54-year old female who died of bronchogenic carcinoma. She had no otologic symptoms. Both inner ears are normal. The lateral canal crista is shown. The postmortem time was 19 hours.
  • Gender: Female
  • Age(yrs.): 54
  • otologic_dx:

    Normal

  • Title: Normal lateral canal crista, R-61
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 672
  • Comments: This case is that of a 54-year old female who died of bronchogenic carcinoma. She had no otologic symptoms. Both inner ears are normal. The lateral canal crista is shown. The postmortem time was 19 hours.
  • Gender: Female
  • Age(yrs.): 54
  • otologic_dx:

    Normal

  • Title: Normal lateral canal crista, R-61
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 672
  • Comments: This case is that of a 54-year old female who died of bronchogenic carcinoma. She had no otologic symptoms. Both inner ears are normal. The lateral canal crista is shown. The postmortem time was 19 hours.
  • Gender: Female
  • Age(yrs.): 54
  • otologic_dx:

    Normal

  • Title: Normal lateral canal crista, R-61
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 672
  • Gender: Female
  • Age(yrs.): 54
  • otologic_dx:

    Normal

  • Title: R101 streptomycin
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 31
  • Comments: Audio-cytocochleogram
  • Gender: Male
  • Age(yrs.): 69
  • otologic_dx:

    1. Neomycin ototoxicity, severe, bilateral

    2. Organ of Corti, atrophy, severe, secondary to #1, bilateral

    3. Neuronal atrophy, cochlear, retrograde, severe, secondary to #1, bilateral

    4. Spiral ligament, atrophy, secondary to #1, bilateral

    5. Reissner’s membrane

  • Title: Streptomycin
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • Comments: Audio-cytocochleogram
  • Title: R81 Streptomycin
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 473
  • Gender: Male
  • Age(yrs.): 55
  • otologic_dx:

    1. Streptomycin, ototoxicity

    2. Anomaly, saccule, bilateral

    a) Utriculoendolymphatic valves, absent

    b) Utricles and saccules in wide communication with each other and with endolymphatic sinuses

    3. Artifact

  • Title: R161 Streptomycin
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 538
  • Gender: Female
  • Age(yrs.): 35
  • otologic_dx:

    1. Streptomycin ototoxicity, manifested clinically by ataxia and pathologically by loss of hair cells in all cristae, bilateral

    2. Normal utricular and saccular maculae

    3. Serofibrinous mastoiditis, inactive, bilateral

    4. Large pneumatized cell, petrous

  • Title: R371 Streptomycin
  • Chapter: Intoxication
  • Chapter section: Streptomycin
  • TB Case Number: 538
  • Gender: Female
  • Age(yrs.): 35
  • otologic_dx:

    1. Streptomycin ototoxicity, manifested clinically by ataxia and pathologically by loss of hair cells in all cristae, bilateral

    2. Normal utricular and saccular maculae

    3. Serofibrinous mastoiditis, inactive, bilateral

    4. Large pneumatized cell, petrous

  • Title: R185 Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 700
  • Gender: Female
  • Age(yrs.): 50
  • otologic_dx:

    1. Ototoxic deafness caused by parenteral kanamycin and manifested by severe loss of hair cells of both cochleae

    2. Acute right otitis media

    3. Acute labyrinthitis, mild, early, right

    4. Postmortem irrigation with fixative, right ear

  • Title: Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 700
  • Gender: Female
  • Age(yrs.): 50
  • otologic_dx:

    1. Ototoxic deafness caused by parenteral kanamycin and manifested by severe loss of hair cells of both cochleae

    2. Acute right otitis media

    3. Acute labyrinthitis, mild, early, right

    4. Postmortem irrigation with fixative, right ear

  • Title: Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 700
  • Gender: Female
  • Age(yrs.): 50
  • otologic_dx:

    1. Ototoxic deafness caused by parenteral kanamycin and manifested by severe loss of hair cells of both cochleae

    2. Acute right otitis media

    3. Acute labyrinthitis, mild, early, right

    4. Postmortem irrigation with fixative, right ear

  • Title: Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 700
  • Comments: Audio-cytocochleogram
  • Gender: Female
  • Age(yrs.): 50
  • otologic_dx:

    1. Ototoxic deafness caused by parenteral kanamycin and manifested by severe loss of hair cells of both cochleae

    2. Acute right otitis media

    3. Acute labyrinthitis, mild, early, right

    4. Postmortem irrigation with fixative, right ear

  • Title: R221 Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 174
  • Gender: Female
  • Age(yrs.): 50
  • otologic_dx:

    1. Aminoglycoside ototoxicity, kanamycin, severe, bilateral

    2. Organ of Corti, hair cell, loss, severe, kanamycin ototoxicity, severe

    3. Neurons, cochlear, normal, bilateral

    4. Stria vascularis, atrophy, moderate, bilateral

    5. Tympanomastoiditis, acute

  • Title: Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 82
  • Gender: Female
  • Age(yrs.): 27
  • otologic_dx:

    1. Aminoglycoside, ototoxicity, kanamycin, cochlear, bilateral

    2. Organ of Corti, hair cells, atrophy, basal turn, kanamycin ototoxicity, bilateral

  • Title: R127 Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 174
  • Gender: Female
  • Age(yrs.): 50
  • otologic_dx:

    1. Aminoglycoside ototoxicity, kanamycin, severe, bilateral

    2. Organ of Corti, hair cell, loss, severe, kanamycin ototoxicity, severe

    3. Neurons, cochlear, normal, bilateral

    4. Stria vascularis, atrophy, moderate, bilateral

    5. Tympanomastoiditis, acute

  • Title: R161 Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 174
  • Gender: Female
  • Age(yrs.): 50
  • otologic_dx:

    1. Aminoglycoside ototoxicity, kanamycin, severe, bilateral

    2. Organ of Corti, hair cell, loss, severe, kanamycin ototoxicity, severe

    3. Neurons, cochlear, normal, bilateral

    4. Stria vascularis, atrophy, moderate, bilateral

    5. Tympanomastoiditis, acute

  • Title: R182 Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 174
  • Gender: Female
  • Age(yrs.): 50
  • otologic_dx:

    1. Aminoglycoside ototoxicity, kanamycin, severe, bilateral

    2. Organ of Corti, hair cell, loss, severe, kanamycin ototoxicity, severe

    3. Neurons, cochlear, normal, bilateral

    4. Stria vascularis, atrophy, moderate, bilateral

    5. Tympanomastoiditis, acute

  • Title: L-251 Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 577
  • Gender: Female
  • Age(yrs.): 19
  • otologic_dx:

    1. Kanamycin deafness, bilateral, severe

    2. Hair cell degeneration, cochleae, bilateral, near total, due to kanamycin ototoxicity

  • Title: L201 Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 577
  • Gender: Female
  • Age(yrs.): 19
  • otologic_dx:

    1. Kanamycin deafness, bilateral, severe

    2. Hair cell degeneration, cochleae, bilateral, near total, due to kanamycin ototoxicity

  • Title: L231 Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 577
  • Gender: Female
  • Age(yrs.): 19
  • otologic_dx:

    1. Kanamycin deafness, bilateral, severe

    2. Hair cell degeneration, cochleae, bilateral, near total, due to kanamycin ototoxicity

  • Title: L-251 Kanamycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Kanamycin
  • TB Case Number: 577
  • Gender: Female
  • Age(yrs.): 19
  • otologic_dx:

    1. Kanamycin deafness, bilateral, severe

    2. Hair cell degeneration, cochleae, bilateral, near total, due to kanamycin ototoxicity

  • Title: L283 Gentamicin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Gentamycin
  • TB Case Number: 17
  • Gender: Male
  • Age(yrs.): 51
  • otologic_dx:

    1. Gentamicin ototoxicity, severe

    2. Severe (near total) loss of inner and outer hair cells, secondary to #1, bilateral

    3. Pigmentary deposit, organ of Corti

    4. Hemorrhage, intracochlear, scalae media and vestibuli, upper basal and middle turns

  • Title: Neomycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Neomycin
  • TB Case Number: 748
  • Comments: Audio-cytocochleogram
  • Gender: Female
  • Age(yrs.): 87
  • otologic_dx:

    1. Ototoxicity, neomycin, neomycin deafness

  • Title: Neomycin Ototoxicity
  • Chapter: Intoxication
  • Chapter section: Neomycin
  • TB Case Number: 748
  • Comments: Audio-cytocochleogram
  • Gender: Female
  • Age(yrs.): 87
  • otologic_dx:

    1. Ototoxicity, neomycin, neomycin deafness

  • Title: Neomycin Ototoxicity R231
  • Chapter: Intoxication
  • Chapter section: Neomycin
  • TB Case Number: 748
  • Gender: Female
  • Age(yrs.): 87
  • otologic_dx:

    1. Ototoxicity, neomycin, neomycin deafness

  • Title: Erythromycin Ototoxicity R-181
  • Chapter: Intoxication
  • Chapter section: Erythromycin
  • TB Case Number: 911
  • Comments: Strial edema
  • Gender: Female
  • Age(yrs.): 57
  • otologic_dx:

    1. Sensorineural hearing loss, moderate, symmetric, bilateral, presumed secondary to erythromycin ototoxicity

    2. Stria vascularis edema, pathologic, bilateral, presumed secondary to erythromycin ototoxicity